The proposed research project will “leverage the infrastructure of the national Chasing COVID Cohort, a large and geographically diverse community-based U.S. cohort, to tailor and test the effectiveness of a brief digital attitudinal inoculation intervention to increase vaccination among adults with anxiety or depression symptoms.

Aim 1: Characterize the relationship between symptoms of anxiety and depression and vaccine/booster uptake, and other related determinants of vaccine uptake (including endorsement of COVID-19 misinformation and vaccine hesitancy) among those with and without anxiety/depression.

Aim 2: Adapt and pilot an evidence-based attitudinal inoculation intervention to increase COVID-19 vaccination and boosting among adults with symptoms of anxiety or depression.

Aim 3: Determine the effectiveness of two brief digital attitudinal inoculation intervention strategies compared with conventional public health messaging for increasing vaccine uptake in un/undervaccinated and unboosted adults.”